What are the dangers of doing this? On the two MCUs I'm looking at right now, you simply change a fuse to have the reset pin function as a RESET pin, or as an I/O pin.
Will I still be able to program it? What won't I be able to do? Will I be able to change the fuse back once I change it to I/O?
EDIT: So I mustered up the guts to actually program the fuse to make the reset pin into an I/O pin and.......
AvrStudio showed me a popup saying that it'd be impossible to program it if I did so. So I didn't.

So, that makes me wonder, how else is there to program chips without an ISP programmer? I think it's time for me to look into bootloading....